NFL Point Spreads Week 5: Best Picks Against the Spread

Payton Matthews | Updated Sep 30, 2019

nick chubb browns

If you are a fan of one of those 0-4 teams in the NFL, go ahead and forget the postseason. Just one team under the current format (since 1990) has made it after losing its first four.

Here’s a quick look at all the Week 5 matchups with Sports Interaction NFL odds. Games Sunday unless noted. Detroit and Miami on the bye.

NFL Week 5 Odds

Los Angeles Rams at Seattle Seahawks, Thursday

The Rams swept their NFC West rivals last year but both were down to the wire. L.A. was upset by Tampa Bay on Sunday in allowing the most points it ever has in a home game. Seattle didn’t have much trouble in a victory at winless Arizona.

Point spread: Seahawks -1

Pick ATS: Los Angeles

Arizona Cardinals at Cincinnati Bengals

Short week for Cincinnati, which entered Monday night’s game winless. Arizona also is yet to win. Rookie No. 1 overall pick Kyler Murray has been a bit up-and-down. He threw for 241 yards with an interception and rushing score in Sunday’s home loss to Seattle.

Point spread: Bengals -4.5

Pick ATS: Cincinnati

Buffalo Bills at Tennessee Titans

Buffalo was knocked from the ranks of the unbeatens with a 16-10 home loss to New England on Sunday. Starting quarterback Josh Allen was knocked out of the game with a possible concussion so he’s in question here. Tennessee was a 24-10 upset winner in Atlanta. Marcus Mariota threw three first-half touchdown passes, two to rookie A.J. Brown.

Point spread: Titans -2.5

Pick ATS: Tennessee

Chicago Bears vs. Oakland Raiders

Usually, NFL games played in London – this at Tottenham Hotspur Stadium – kick off at 9:30 a.m. ET, but this one is at 1 p.m. ET. Of course, Chicago’s defence got massively better on the eve of last season when the Bears sent two first-round draft picks (other picks involved on both sides) for Oakland’s best defensive player in Khalil Mack. Have to say Chicago won that deal even at the high price, and expect Mack to play like a madman here. The Bears won’t have starting QB Mitchell Trubisky due to a separated shoulder.

Point spread: Bears -4.5

Pick ATS: Chicago

Tampa Bay Bucs at New Orleans Saints

Tampa Bay was the biggest upset winner of Week 4, stunning the Rams 55-40. Jameis Winston threw for 385 yards and four touchdowns. Chris Godwin caught two of them. It was the most points the Bucs have ever scored. Again without Drew Brees, the Saints were home dogs to Dallas on Sunday but won 12-10. It was the first time New Orleans ever won a game under Coach Sean Payton when not scoring a TD.

Point spread: Saints -4.5

Pick ATS: New Orleans

Minnesota Vikings at New York Giants

The Vikings were shut down offensively in a 16-6 loss in Chicago on Sunday. Dalvin Cook had rushed for at least 100 yards in each of the first three games but was held to 35 on 14 carries. The Giants are 2-0 under rookie quarterback Daniel Jones following a 24-3 win over Washington. With Saquon Barkley out injured, backup running back Wayne Gallman had two TDs.

Point spread: Vikings -4.5

Pick ATS: Minnesota

New York Jets at Philadelphia Eagles

Both clubs on extra rest as the Jets were on the Week 4 bye, while the Eagles were 34-27 upset winners in Green Bay last Thursday night. Jordan Howard had three touchdowns. New York hopes to have starting quarterback Sam Darnold return after missing the past two games due to contracting mono.

Point spread: Eagles -14

Pick ATS: New York

Baltimore Ravens at Pittsburgh Steelers

Used to be one of the NFL’s best rivalries, but Pittsburgh is a shell of itself right now, entering Monday night’s Week 4 game vs. Cincinnati at 0-3. Baltimore was upset 40-25 at home by Cleveland on Sunday. It was the second straight week the Ravens allowed at least 500 yards.

Point spread: Ravens -4

Pick ATS: Pittsburgh

New England Patriots at Washington Redskins

New England looked mortal but did improve to 4-0 with Sunday’s 16-10 win in Buffalo. Tom Brady was held to 150 yards passing with a pick, but the Pats forced four turnovers. Who will be at quarterback for Washington here? Case Keenum was pulled in Sunday’s 24-3 loss at the Giants for rookie Dwayne Haskins, but Haskins looked overmatched in his first regular-season action. Could be Colt McCoy under centre.

Point spread: Patriots -15.5

Pick ATS: Washington

Jacksonville Jaguars at Carolina Panthers

Carolina will again be without QB Cam Newton. The former No. 1 overall pick has missed the previous two with a type of foot injury that usually takes several weeks to heal.  Rookie Gardner Minshew led Jacksonville back from a 17-3 hole in Denver and a 26-24 win on Josh Lambo’s 33-yard field goal as time expired. Leonard Fournette rushed for a career-high 225 yards.

Point spread: Panthers -3.5

Pick ATS: Jacksonville

Atlanta Falcons at Houston Texans

Atlanta was upset at home by Tennessee on Sunday, 24-10, despite Matt Ryan throwing for 397 yards. The Falcons were stopped on three fourth-down plays. Houston was upset at home by Carolina, 16-10. Deshaun Watson was held to 160 yards passing.

Point spread: Texans -5

Pick ATS: Houston

Denver Broncos at Los Angeles Chargers

Pro Bowl running back Melvin Gordon ended his holdout last week but didn’t play in the Chargers’ 30-10 win in Miami – he should here. Philip Rivers threw for 310 yards and two touchdowns. Austin Ekeler, whose fantasy stock will take a huge hit with Gordon’s return, had two touchdowns. The Broncos are winless and also lost excellent young linebacker Bradley Chubb to a season-ending torn ACL on Sunday.

Point spread: Chargers -6.5

Pick ATS: Los Angeles

Green Bay Packers at Dallas Cowboys

Probably the marquee game of Week 5 with both leading their respective divisions. Green Bay is tied for first in the NFC North after losing at home to Philadelphia last Thursday. Top receiver Davante Adams suffered a toe injury and is in question for this week. Dallas held the Saints without a TD on Sunday but still lost. The Cowboys managed only 257 yards and turned it over three times.

Point spread: Cowboys -3.5

Pick ATS: Dallas

Indianapolis Colts at Kansas City Chiefs

Sunday night game. These clubs met in Kansas City in last year’s Divisional Round of the playoffs and the Chiefs rolled to victory. That would prove to be the final NFL game for now-retired Colts QB Andrew Luck. Not clear if Indy will have No. 1 receiver T.Y. Hilton after he missed Sunday’s loss to Oakland with a quad injury.

Point spread: Chiefs -11

Pick ATS: Kansas City

Cleveland Browns at San Francisco 49ers, Monday

The Niners about as rested as possible as they were on the bye in Week 4 and are unbeaten thanks to a vastly improved defence. Cleveland looked like the Super Bowl contender it was hyped to be with Sunday’s 40-25 win in Baltimore. Nick Chubb rushed for 165 yards and three touchdowns.

Point spread: 49ers -3.5

Pick ATS: Cleveland