How to Bet Week 10 of the 2025 NFL Season: NFC powerhouses meet on Monday Night Football
It’s a stacked Week 10 schedule in the NFL, with the league returning to Germany, while a few heavyweights meet in the prime-time slots.
We’re back with picks and predictions for all the Week 10 prime-time games and couple Sunday afternoon matinees.
Here’s everything you need to know to bet Week 10 of the 2025 NFL season.
Don’t forget to check out Sports Interaction’s complete list of NFL game odds, NFL futures and NFL specials and props.
TNF Raiders at Broncos
Two AFC West teams trending in opposite directions kick off Week 10 in the NFL. The Broncos are an NFL-best 7-2 thanks to a six-game win streak, while the Raiders are last in the division at 2-6.
Prior to last week’s overtime loss, Las Vegas was absolutely smacked around in their two previous losses, 31-0 against Kansas City and 40-6 against the Colts. That lack of scoring is concerning considering the Raiders are facing a Broncos defence that allows just 18.4 points per game, the fourth-best mark in the NFL.
Las Vegas basically waved the white flag on the season at Tuesday’s trade deadline, shipping top receiver Jakobi Meyers to Jacksonville. That should mitigate the loss of Denver cornerback Patrick Surtain II.
And how can you trust Raiders quarterback Geno Smith against a Broncos defence that ranks top-three in the NFL? Smith has been terrible this season, completing 67.2 per cent of passes with 11 TDs and a league-high 11 interceptions.
Pick: Broncos -9
Falcons at Colts (in Berlin)
The NFL heads to Germany this week with the 7-2 Colts, looking to bounce back from last week’s loss, facing the 3-5 Falcons.
Indianapolis has been one of the most surprising teams of the season behind none other than Daniel Jones. Danny Dimes was a castoff last year in New York, but he’s turned into Indiana Jones with the Colts, tossing for an NFL-best 2,404 yards with 14 TDs and six interceptions.
Atlanta will counter with Michael Penix Jr., who is coming off his best game of the season in a 24-23 loss against New England. Penix threw for 221 yards and three TDs, with Drake London converting nine receptions into 118 yards and three scores.
I’d be more inclined to give the points if this were a true home game for Indy, but it’s long travel for both teams and I think the Falcons stay in this thing.
Pick: Falcons +6.5
Rams at 49ers
The NFC West has proven to be the most competitive division in football this season, with three teams each posting six wins. Two of those teams, the 6-2 Rams and the 6-3 49ers, meet in San Francisco in Week 10.
History says take the Under in this game. Three of the last four head-to-heads have finished below the number, with this season’s earlier matchup finishing at 49 total points with overtime.
L.A.’s defence has hit another level over the last few weeks, holding Baltimore, Jacksonville and New Orleans to a combined 20 points over a three-game win streak.
San Francisco has been fairly inconsistent this season and they haven’t really dominated any games. I think this Rams defence will smother the Niners and keep this a low scoring game.
Pick: Under 49.5
SNF Steelers at Chargers
Sunday Night Football gives us a great matchup from the AFC, with the 5-3 Steelers visiting the 6-3 Chargers.
Pittsburgh is looking to build off a big win against the Colts last week. After struggling for the first half of the season, the defence really stepped up against Indy, sacking Daniel Jones five times and generating six turnovers.
That success should continue against a Chargers offensive line that has allowed Justin Herbert to be sacked a ridiculous 28 times this season. The protection for Herbert is even more concerning with OT Joe Alt done for the year.
This should be a great game and I’m expecting it to come down to the wire.
Pick: Steelers +3
MNF Eagles at Packers
Arguably the best Monday Night Football game of the year is on tap this week as the 5-2-1 Packers host the 6-2 Eagles in a battle of NFC division leaders.
It’s hard not to like Philadelphia in this spot. The Eagles went into last week’s bye off back-to-back convincing wins, so they should be rested and confident.
Philly’s offence has looked much better, with Jalen Hurts throwing for 1,068 yards with 10 TDs and just one interception over his last four games. Saquon Barkley and A.J. Brown have also had time to recover from nagging injuries, so that could be a major factor this week.
Green Bay is coming off an absolutely shocking 16-13 loss against Carolina last week, despite entering the contest as massive 13.5-point favourites. The Packers disappointed bettors and more importantly, burned me in my survivor pool.
Jordan Love will be throwing to a banged up receiving group, which is only complicated by a matchup against an Eagles defence that ranks fourth in the NFL in opponent pass rate.
Fly, Eagles, fly.
Pick: Eagles +2.5, Under 44.5
