How to Bet the Buffalo Bills in 2025: Futures Odds, Props and Season Preview

Bills 2024 Season Recap and 2025 Outlook

Buffalo went 13–4 in 2024, capturing a fifth straight AFC East title before falling in overtime to the Kansas City Chiefs in the AFC Championship. Quarterback Josh Allen, fresh off an MVP campaign, returns with a retooled supporting cast and a revamped defense that addressed many offseason needs. On the Sports Interaction 2025 NFL Futures board, the Bills are priced at –325 to win the AFC East, +340 to win the AFC Championship, and +700 to win the Super Bowl. Their regular-season win total sits at 10.5 (Over +115, Under –143).

Key Bills Offseason Moves and Roster Changes

Buffalo retained its core while reinforcing weak spots. They extended WR Khalil Shakir on a four-year deal after his breakout 2024 campaign and locked in LB Terrel Bernard and DE Greg Rousseau. Big-name additions included Joey Bosa, Larry Ogunjobi, Michael Hoecht (though temporarily suspended for six games), and Joshua Palmer to bolster both lines and pass catchers. They also re-signed S Damar Hamlin and added S Darrick Forrest, while TRB Kaiir Elam was traded to the Cowboys and Von Miller was released. 

In the draft, Buffalo swung big on defense with first-round cornerback Maxwell Hairston, and followed up with DT T.J. Sanders, DE Landon Jackson, and DT Deone Walker, investing heavily in new front-line talent.

Projected Bills Starting Lineup for 2025

Josh Allen leads the offense behind what should be a formidable offensive line anchored by Dion Dawkins and Darrick Forrest. The ground game is anchored by James Cook, with Khalil Shakir, Stefon Diggs, and Joshua Palmer forming the top wide receiver trio. Defensively, Joey Bosa, Larry Ogunjobi, and Michael Hoecht anchor the front, while Christian Benford, Tre’Davious White, and rookie Hairston (once healthy) anchor the secondary. Matt Milano, Terrel Bernard, and Darrick Forrest form a capable linebacker group.

Bills 2025 Regular Season Schedule 

Buffalo opens the season strong with home games and favorable matchups. They finish the season with key AFC East battles that could determine the division title, giving them early points of leverage in the win total market.

Week 1 – Sunday, September 7
Home vs. Baltimore Ravens

Week 2 – Sunday, September 14
At New York Jets

Week 3 – Thursday, September 18
Home vs. Miami Dolphins

Week 4 – Sunday, September 28
Home vs. New Orleans Saints

Week 5 – Sunday, October 5
Home vs. New England Patriots

Week 6 – Monday, October 13
At Atlanta Falcons

Week 7 – Bye

Week 8 – Sunday, October 26
At Carolina Panthers

Week 9 – Sunday, November 2
Home vs. Kansas City Chiefs

Week 10 – Sunday, November 9
At Miami Dolphins

Week 11 – Sunday, November 16
Home vs. Tampa Bay Buccaneers

Week 12 – Thursday, November 20
At Houston Texans

Week 13 – Sunday, November 30
At Pittsburgh Steelers

Week 14 – Sunday, December 7
Home vs. Cincinnati Bengals

Week 15 – Sunday, December 14
At New England Patriots

Week 16 – Sunday, December 21
At Cleveland Browns

Week 17 – Sunday, December 28
Home vs. Philadelphia Eagles

Week 18 – Sunday, January 4
Home vs. New York Jets

How to Bet on the Bills in 2025

The Over 10.5 wins is the most attractive preseason wager at +115. Buffalo returns most of a 2024 roster and faces a division without a clear breakout team. Taking the AFC East title at –325 locks in early value, especially if one of their rivals slips in Week 1.

Among futures, the +340 AFC Championship line makes sense for small speculative tickets, while the +700 Super Bowl bet is best saved for in-season fade or futures boosts.

On props, the Allen passing yards and TD lines align with his MVP season, but the under may offer value later if his receiving corps takes a step back. Cook over on rushing yards looks fair given his workhorse usage, and Diggs over on receiving yards or TDs fits a high-volume target in the passing game. Stay alert for weather swings and injury updates that might juice these lines further.

Bills Futures Odds and Player Prop Lines

Josh Allen Passing Yards – 3750.5 (Over –125, Under –105)

Allen has gone over this number in four of the past five seasons. With a strong offensive line and consistency in Ken Dorsey’s system, the over is a solid play. If Buffalo leans more on the run or deals with injuries in the receiving corps, the under could come into play, but as long as Allen stays upright, 4,000 yards is well within reach.

Josh Allen Passing Touchdowns – 27.5 (Over –125, Under –105)

Allen has thrown at least 35 touchdown passes in three of his last four seasons. Even if Buffalo leans more on the ground in short-yardage situations, he remains one of the most dangerous quarterbacks in the red zone. The over is a confident bet based on past production and red zone usage.

James Cook Rushing Yards – 1025.5 (Over –115, Under –115)

Cook ran for over 1,100 yards last season and should see an even bigger workload in 2025. Damien Harris is gone, and there’s no clear backup expected to take touches away. As long as Cook stays healthy, he should have every opportunity to clear this number. The over is a reasonable play.

Bills 2025 Season Risks and Concerns

Key storyline to monitor includes injuries to Shakir and rookie CB Maxwell Hairston, both week-to-week. Lives at the safety position are thin, especially with Hamlin’s injury history and newly added Darrick Forrest having limited snaps. On defense, Hoecht’s suspension and Ogunjobi’s PED suspension could delay the integration of new front-line pieces. If Josh Allen misses time or efficiency drops, the offense’s thin receiver depth could struggle to compensate.

Buffalo Bills 2025 Record Prediction and Preview Bets

Buffalo looks built to win the AFC East again, and most likely finish with 12–5, grabbing home-field advantage in Round 1.

Best bets: Over 10.5 wins at +115, AFC East winner at –325, and small futures plays on AFC Championship. For props, Cook rushing yards over, Diggs receiving yards over, and a cautious play on Allen passing yards or TDs if public buzz grows. Exact wins around 12 (+550) offers solid value if you lean bullish.