Eagles vs. 49ers Point Spread: NFL Week 4 Odds, Prediction

Andrew Rogers | Updated Oct 01, 2020

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The 2020 season is already getting away from the Eagles – and a date with a recovering 49ers team won’t help matters as the teams square off Sunday night.

October 04, 2020, 8:20 PM ET
Levi's Stadium
Pointspread +8 -112
Moneyline +285
Over / Under o +46.5


Betting Action


Pointspread -8 -108
Moneyline -347
Over / Under u +46.5


Betting Action


The Eagles have two losses and a tie over their first three games, are saddled with a minus-29 point differential in that span and are a one-touchdown underdog against a San Francisco team that will have at least one marquee player back in action.

NFL Week 4 Point Spread and Betting Analysis

The defending NFC champions are seven-point favourites for the third time in their first four games; they went 1-1 ATS in the first two, dropping a 24-20 decision to the rival Arizona Cardinals in Week 1 before trouncing the New York Jets 31-13 the following week. The 49ers are 2-1 SU and ATS on the season, and have covered in five of their past seven overall. That’s good enough for Sports Interaction bettors, with 63 percent taking the home team ATS.

The total has an even larger majority attached, with 72 percent of respondents siding with the O46. That plays into Philadelphia’s most significant totals trend, with the Eagles having cashed the Over in each of their previous five road games (with an average of 54.2 points scored in those five outings). And these NFC rivals have finished above the total in seven of their previous 10 head-to-head meetings, though their last two have fallen under the number.

Philadelphia Eagles

The batteries might soon be flying in Philly, with quarterback Carson Wentz off to a truly terrible start. Wentz has completed less than 60 percent of his passes on the season while throwing for three touchdowns and a league-worst six interceptions. He has thrown multiple INTs in all three games the Eagles have played, and hasn’t been helped in the least by a leaky offensive line that has already allowed 11 sacks – including eight in Week 1 to Washington.

San Francisco 49ers

The decimated 49ers are expected to welcome back their biggest offensive threat this weekend, with tight end George Kittle returning to full practice after missing the previous two games with a knee injury. And while the 49ers didn’t need him en route to one-sided wins over the Jets and Giants, they’ll be happy to have him back: Kittle had just four catches for 44 yards in the opener but is coming off back-to-back 85-plus-reception, 1,000-plus yard seasons.

NFL Prediction: Who Will Win Eagles vs. 49ers?