Cardinals vs. Seahawks Point Spread: NFL Week 11 Odds, Prediction

Andrew Rogers | Updated Nov 17, 2021

The return of the Seattle’s starting quarterback from injury didn’t exactly translate into success for the Seahawks last week.

November 21, 2021, 4:25 PM ET
CenturyLink Field
Pointspread +4.5 -101
Moneyline +170
Over / Under o +45


Betting Action


Pointspread -4.5 -119
Moneyline -204
Over / Under u +45


Betting Action


The Arizona Cardinals can only hope their No. 1 QB is more successful in his return to action – if it happens – as they visit Lumen Field on Sunday afternoon. The Cardinals are still the class of the NFC West and will look to remain unbeaten on the road – a task that becomes much easier if Kyler Murray is back on the field.

NFL Week 11 Point Spread and Betting Analysis

The Cardinals being favoured in one of the most hostile road environments in football suggests that oddsmakers believe Murray will return this week after missing the previous two games with an ankle injury. The jury is still out among Sports Interaction bettors, however, with only 60 percent taking the visitors. The Cardinals are one of the strongest cover teams in the NFL this season at 7-3 ATS, while the Seahawks are 5-4 overall but just 2-2 at home.

The total for Sunday’s key divisional showdown is set at 49, and bettors are fully buying into the Seahawks’ impressive Under run this season. A whopping 75 percent of Sports Interaction respondents are siding with the U49 play, no doubt driven by the fact that the Seahawks are 1-7-1 O/U for the season and are seeing an average of just 40.8 total points per game. These teams came in right on that total in their last meeting, a 28-21 Seattle win last Nov. 19.

Arizona Cardinals

The Cardinals looked surprisingly strong without Murray in a 31-17 win over the San Francisco 49ers, but came crashing down to Earth in a 34-10 drubbing at the hands of the visiting Carolina Panthers. Murray’s return would go a long way toward re-establishing the Cardinals as the team to beat in the NFC; he completed 70 percent of his passes for 629 yards with five touchdowns and just one interception in two meetings with the Seahawks last season.

Seattle Seahawks

Russell Wilson saw the field last week for the first time since Oct. 7 – and to say he wasn’t sharp would be a gross understatement. Wilson, who sat out several weeks with a finger injury, completed just 20 of 40 pass attempts for 161 yards with zero touchdowns and two interceptions. Wilson had an up-and-down showing vs. Arizona in 2020, throwing for 585 yards and five touchdowns but also getting picked off three times in those two games.

NFL Prediction: Who Will Win Cardinals vs. Seahawks?