The Bills have already clinched the AFC East for the fifth straight season, but with a 10-2 record this team has their sights set on the one seed in the AFC and a trio of playoff victories. Sunday’s a huge opportunity for the Rams to keep in the battle for the NFC West. At 6-6, L.A. is a game behind first in the division and game above last.

Outside of a home loss to Philadelphia two weeks ago, the Rams have proven to be able to compete with the NFL’s best: defeating San Francisco and Minnesota, and losing one-score games to Detroit and Green Bay. Only Baltimore and Houston have gotten the better of Buffalo this season, who just steamrolled the 49ers in the snow last week to make it seven straight wins.

Kickoff at SoFi Stadium gets started at 4:25 p.m. EST on Sunday, with the Bills opening as a -225 moneyline favourite on the road and the over-under at 49 on the NFL odds.

NFL Point Spread and Betting Analysis

Buffalo has handled L.A. with ease of late, winning and covering in five of their last six meetings. The Bills most recently made the trip to play the Rams on the opening weekend of the 2022 NFL season (the Stefon Diggs “I’m him” meme game). This time around, it should be quarterback Josh Allen screaming that to whoever will listen — last week’s performance solidified Allen as the favourite to win his first NFL MVP at -250 odds.

Eight of the last 10 Bills–Rams contests have finished under the total, but Buffalo’s been an under team on the road this season. In Buffalo’s six road outings this season, the under is 4-2 thanks to the Bills allowing over 20 points just twice. L.A.’s scored over 20 points just one time at home this season — their home opener back on September 22.

Buffalo Bills

Josh Allen appears to be capable of doing it all. The star quarterback’s passing and receiving touchdown (at the same time) last week proved that narrative, as Allen became the seventh player in the Super Bowl era to pass, rush, and receive a touchdown in the same game. 

As they often do, the Bills changed up the offensive philosophy last week and rushed the ball 38 times while passing 18 times in snowy conditions. This includes kneel-downs from Mitchell Trubisky to end the 35-10 victory, so excluding those rushes the Bills ran 34 times for 223 yards (6.55 yards per carry). James Cook left the exclamation point with a 65-yard score, but both of Ray Davis and Ty Johnson got involved too. This is all just another tell that the Bills are ready to compete for a championship — especially if tight end Dalton Kincaid, receiver Keon Coleman, and defensive tackle DeWayne Carter all return from injuries this week.

Los Angeles Rams

Don’t let last week’s 21-14 road victory at New Orleans gloss over the fact the Rams were shutout in the first half. Offence continues to be a lingering worry in L.A. as crunch time approaches. As mentioned above, the Rams have gone over 20 points just once on home field this season — which isn’t good offence for an offence led by Matthew Stafford and equipped with Kyren Williams, Puka Nacua, and Cooper Kupp.

Last week the Rams capitalized on every opportunity — talking about a 3/3 red zone performance — but fact is they need more opportunities. Stafford’s cracked the 300-yard threshold once this season, and the Rams rank 26th in rushing yards per game this season. Neither trend will be good enough this weekend against an elite team in Buffalo.

NFL Prediction: Who Will Win Bills vs. Rams?