The Buffalo Bills are road favourites for the first time since the 2017 campaign as they travel to the Meadowlands to take on Saquon Barkley and the New York Giants.
The Bills are seeking a second straight win at MetLife Stadium after a stunning, come-from-behind victory against the New York Jets last weekend.
NFL Point Spread and Betting Analysis
The G-Men opened as 2.5-point home dogs at Sports Interaction. The point spread dropped half a point to +2 by midweek. The game total opened at 42.5 and quickly moved up a point to 43.5. The action is near split on the spread with 51 percent of the bets on the Bills. The handle isn’t as even on the Over/Under line. About 65 percent of Sports Interaction customers expect this game to go Over 43.5 points.
Buffalo Bills at NY Giants
- Buffalo Bills -114 -1
- NY Giants -106 +1
Buffalo has long been one of the cellar dwellers in the AFC, but the club has a knack for following up strong performances. The Bills are 4-1 against the spread in their last five games coming off an outright win.
The Giants are 1-6-1 ATS in their last eight home contests and 2-8 against the number in their last 10 September games.
The Bills defence held the Jets in check last weekend. Low-scoring games have been commonplace for games involving Buffalo. The Under is 7-1 in the Bills’ last eight away dates.
Buffalo Bills
The final score might not show it, but the Bills completely dominated the Jets in Week 1. Buffalo came from down 16 to win outright 17-16, but the club outgained Gang Green 358 to 203 in yards.
Eli Manning and his creaky, 38-year-old frame could be in trouble against the Bills’ pass rush. Buffalo sacked Sam Darnold four times in Week 1.
Josh Allen doesn’t mind defensive pressure. The second year QB rushed for 38 yards and a touchdown against the Jets. He gained over 600 yards on the ground last season and he already has nine career rushing touchdowns.
New York Giants
Expect to see second year running back Saquon Barkley feature early and often for the Giants. New York will likely be without wide receiver Sterling Shepard. The fourth year playmaker out of Oklahoma is in the concussion protocol after suffering a blow to the head in last weekend’s loss to the Giants. Shepard and Golden Tate were expected to be the top two wide receiver targets for Eli Manning this season. Tate is out for the first four games due to suspension.
Who Will Win Bills vs. Giants?
Line History
Sports Interaction customers are placing their bets on:
time | fav | line | total |
---|---|---|---|
Opening 9 Sep 2:07am | BUF | -2.5 -109 | O +42.5 -110 |
Closing 15 Sep 4:34pm | BUF | -1 -114 | U +44.5 -109 |
Weather

temp | 79 |
condition | sunny |
wind | Northwest 5mph |
Injuries
Ty Nsekhe (T)
Levi Wallace (CB)
Shaq Lawson (DE)
Andre Roberts (WR)
Mitch Morse (C)
Taron Johnson (CB)
Jon Feliciano (G)
Tre'Davious White (CB)
Jon Feliciano (G)
Frank Gore (RB)
Corn Elder (CB)
Deandre Baker (CB)
Scott Simonson (TE)
Corey Ballentine (CB)
Lorenzo Carter (LB)
Nick Gates (G)
Darius Slayton (WR)
Sam Beal (CB)
Alec Ogletree (LB)
Mike Remmers (T)
Injuries
player (position) | status | ats*current | o/u* | notes | |
---|---|---|---|---|---|
Ty Nsekhe (T) | Ques Sat | Ankle - 29 / 12 / 19 | 0-1 | 1-1 | + - |
Nsekhe has an ankle injury, and his status for the AFC wild-card round against the Texans is up in the air. |
|||||
Levi Wallace (CB) | Prob Sat | Ankle - 29 / 12 / 19 | 0-1 | 1-1 | + - |
Wallace is nursing a sprained ankle, but it is likely that he will take part in the AFC wild-card round versus the Texans. |
|||||
Shaq Lawson (DE) | Ques Sat | Hamstring - 23 / 12 / 19 | 0-1 | 1-1 | + - |
Lawson is dealing with a hamstring injury, and it is unknown if he will suit up against the Texans in the AFC wild-card round. |
|||||
Andre Roberts (WR) | Ques Sat | Foot - 23 / 12 / 19 | 0-1 | 1-1 | + - |
Roberts is battling a foot injury, and it is unclear if he will play in the AFC wild-card round against the Texans. |
|||||
Mitch Morse (C) | Prob Sun | Lower Body - 21 / 12 / 19 | 1-1 | 1-2 | + - |
Morse exited the previous game due to a lower-body injury, but he will likely be available against the Jets on Sunday. |
|||||
Taron Johnson (CB) | Ques Sat | Finger - 16 / 12 / 19 | 1-2 | 1-3 | + - |
Johnson exited the previous game due to a finger injury, and it is unknown if he will available for Saturday's contest against the Patriots. |
|||||
Jon Feliciano (G) | Ques Sat | Leg - 15 / 12 / 19 | 1-2 | 1-3 | + - |
Feliciano left the previous game with a right leg injury, and it is undetermined if he will line up Saturday against the Patriots. |
|||||
Tre'Davious White (CB) | day-to-day | Shoulder - 15 / 12 / 19 | 1-2 | 1-3 | + - |
White exited Sunday's game with a shoulder injury, and it is unclear if he will return. |
|||||
Jon Feliciano (G) | Ques Sun | Illness - 13 / 12 / 19 | 1-2 | 1-3 | + - |
Feliciano is ailing from an illness, leaving his status for Sunday's matchup versus the Steelers uncertain. |
|||||
Frank Gore (RB) | Prob Sun | Illness - 12 / 12 / 19 | 1-2 | 1-3 | + - |
Gore is ailing from an illness, but it is projected that he will fight it off in time for Sunday's matchup with the Steelers. |
player (position) | status | ats*current | o/u* | notes | |
---|---|---|---|---|---|
Corn Elder (CB) | Out Sun | Illness - 28 / 12 / 19 | 1-0 | 1-0 | + - |
Elder is ailing from an illness and will miss Sunday's game against the Saints as a result. |
|||||
Deandre Baker (CB) | Ques Sun | Knee - 26 / 12 / 19 | 1-0 | 1-0 | + - |
Baker is managing a knee injury, and his status is unclear for Sunday's matchup with the Eagles. |
|||||
Scott Simonson (TE) | I-R | Concussion - 26 / 12 / 19 | 1-0 | 1-0 | + - |
Simonson has landed on the injured reserve list due to a concussion. |
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Corey Ballentine (CB) | Ques Sun | Back - 25 / 12 / 19 | 1-0 | 1-0 | + - |
Ballentine has a back injury, and his status is unknown for Sunday's clash against the Eagles. |
|||||
Lorenzo Carter (LB) | Ques Sun | Knee - 25 / 12 / 19 | 1-0 | 1-0 | + - |
Carter is limited by a knee injury, and it is unknown if it will impact his availability against the Eagles on Sunday. |
|||||
Nick Gates (G) | Ques Sun | Shoulder - 25 / 12 / 19 | 1-0 | 1-0 | + - |
Gates has a shoulder injury, and it is unknown if he will play against the Eagles on Sunday. |
|||||
Darius Slayton (WR) | Prob Sun | Knee - 25 / 12 / 19 | 1-0 | 1-0 | + - |
Slayton is dealing with a knee issue, but it is expected that he will take the field versus the Eagles on Sunday. |
|||||
Sam Beal (CB) | Out Sun | Neck - 22 / 12 / 19 | 2-0 | 2-0 | + - |
Beal left the last contest due to a neck injury. He will not be able to take part in Sunday's game against the Eagles. |
|||||
Alec Ogletree (LB) | Ques Sun | Back - 22 / 12 / 19 | 2-0 | 2-0 | + - |
Ogletree left the last game with an injured back. It is undetermined if he will suit up against the Eagles on Sunday. |
|||||
Mike Remmers (T) | Out Sun | Concussion - 22 / 12 / 19 | 2-0 | 2-0 | + - |
Remmers was removed from the previous game due to a concussion, and he will not pass protocol in time for Sunday's game against the Eagles. |
-
BUFFALO BILLS
23 -
NEW YORK GIANTS
17
Score
Prediction
-
Line History
Sports Interaction customers are placing their bets on:
time fav line total Opening 9 Sep 2:07am BUF -2.5 -109 O +42.5 -110 Closing 15 Sep 4:34pm BUF -1 -114 U +44.5 -109 -
Weather
temp 79 condition sunny wind Northwest 5mph -
Injuries
Ty Nsekhe (T)
Ques Sat Ankle - 29 / 12 / 19Levi Wallace (CB)
Prob Sat Ankle - 29 / 12 / 19Shaq Lawson (DE)
Ques Sat Hamstring - 23 / 12 / 19Andre Roberts (WR)
Ques Sat Foot - 23 / 12 / 19Mitch Morse (C)
Prob Sun Lower Body - 21 / 12 / 19Taron Johnson (CB)
Ques Sat Finger - 16 / 12 / 19Jon Feliciano (G)
Ques Sat Leg - 15 / 12 / 19Tre'Davious White (CB)
day-to-day Shoulder - 15 / 12 / 19Jon Feliciano (G)
Ques Sun Illness - 13 / 12 / 19Frank Gore (RB)
Prob Sun Illness - 12 / 12 / 19Corn Elder (CB)
Out Sun Illness - 28 / 12 / 19Deandre Baker (CB)
Ques Sun Knee - 26 / 12 / 19Scott Simonson (TE)
I-R Concussion - 26 / 12 / 19Corey Ballentine (CB)
Ques Sun Back - 25 / 12 / 19Lorenzo Carter (LB)
Ques Sun Knee - 25 / 12 / 19Nick Gates (G)
Ques Sun Shoulder - 25 / 12 / 19Darius Slayton (WR)
Prob Sun Knee - 25 / 12 / 19Sam Beal (CB)
Out Sun Neck - 22 / 12 / 19Alec Ogletree (LB)
Ques Sun Back - 22 / 12 / 19Mike Remmers (T)
Out Sun Concussion - 22 / 12 / 19Injuries
player (position) status ats*current o/u* notes Ty Nsekhe (T) Ques Sat Ankle - 29 / 12 / 19 0-1 1-1 + - Nsekhe has an ankle injury, and his status for the AFC wild-card round against the Texans is up in the air.
Levi Wallace (CB) Prob Sat Ankle - 29 / 12 / 19 0-1 1-1 + - Wallace is nursing a sprained ankle, but it is likely that he will take part in the AFC wild-card round versus the Texans.
Shaq Lawson (DE) Ques Sat Hamstring - 23 / 12 / 19 0-1 1-1 + - Lawson is dealing with a hamstring injury, and it is unknown if he will suit up against the Texans in the AFC wild-card round.
Andre Roberts (WR) Ques Sat Foot - 23 / 12 / 19 0-1 1-1 + - Roberts is battling a foot injury, and it is unclear if he will play in the AFC wild-card round against the Texans.
Mitch Morse (C) Prob Sun Lower Body - 21 / 12 / 19 1-1 1-2 + - Morse exited the previous game due to a lower-body injury, but he will likely be available against the Jets on Sunday.
Taron Johnson (CB) Ques Sat Finger - 16 / 12 / 19 1-2 1-3 + - Johnson exited the previous game due to a finger injury, and it is unknown if he will available for Saturday's contest against the Patriots.
Jon Feliciano (G) Ques Sat Leg - 15 / 12 / 19 1-2 1-3 + - Feliciano left the previous game with a right leg injury, and it is undetermined if he will line up Saturday against the Patriots.
Tre'Davious White (CB) day-to-day Shoulder - 15 / 12 / 19 1-2 1-3 + - White exited Sunday's game with a shoulder injury, and it is unclear if he will return.
Jon Feliciano (G) Ques Sun Illness - 13 / 12 / 19 1-2 1-3 + - Feliciano is ailing from an illness, leaving his status for Sunday's matchup versus the Steelers uncertain.
Frank Gore (RB) Prob Sun Illness - 12 / 12 / 19 1-2 1-3 + - Gore is ailing from an illness, but it is projected that he will fight it off in time for Sunday's matchup with the Steelers.
player (position) status ats*current o/u* notes Corn Elder (CB) Out Sun Illness - 28 / 12 / 19 1-0 1-0 + - Elder is ailing from an illness and will miss Sunday's game against the Saints as a result.
Deandre Baker (CB) Ques Sun Knee - 26 / 12 / 19 1-0 1-0 + - Baker is managing a knee injury, and his status is unclear for Sunday's matchup with the Eagles.
Scott Simonson (TE) I-R Concussion - 26 / 12 / 19 1-0 1-0 + - Simonson has landed on the injured reserve list due to a concussion.
Corey Ballentine (CB) Ques Sun Back - 25 / 12 / 19 1-0 1-0 + - Ballentine has a back injury, and his status is unknown for Sunday's clash against the Eagles.
Lorenzo Carter (LB) Ques Sun Knee - 25 / 12 / 19 1-0 1-0 + - Carter is limited by a knee injury, and it is unknown if it will impact his availability against the Eagles on Sunday.
Nick Gates (G) Ques Sun Shoulder - 25 / 12 / 19 1-0 1-0 + - Gates has a shoulder injury, and it is unknown if he will play against the Eagles on Sunday.
Darius Slayton (WR) Prob Sun Knee - 25 / 12 / 19 1-0 1-0 + - Slayton is dealing with a knee issue, but it is expected that he will take the field versus the Eagles on Sunday.
Sam Beal (CB) Out Sun Neck - 22 / 12 / 19 2-0 2-0 + - Beal left the last contest due to a neck injury. He will not be able to take part in Sunday's game against the Eagles.
Alec Ogletree (LB) Ques Sun Back - 22 / 12 / 19 2-0 2-0 + - Ogletree left the last game with an injured back. It is undetermined if he will suit up against the Eagles on Sunday.
Mike Remmers (T) Out Sun Concussion - 22 / 12 / 19 2-0 2-0 + - Remmers was removed from the previous game due to a concussion, and he will not pass protocol in time for Sunday's game against the Eagles.