2025 NFL Week 10 Player Props, Fantasy Picks: Riding with running backs

The 2025 NFL season is going full steam ahead as we officially enter the second half of the schedule.

In Week 10’s player props and fantasy picks, I’m focusing on some of the game’s biggest name running backs.

Here’s our top player props and fantasy picks for Week 10.

Sports Interaction

Pick
Odds
Over +91.5
Player Prop
NFL • Atlanta Falcons @ Indianapolis Colts
-115 on Sports Interaction
CLOSED • 11/09/2025
Tally (Win %)
0-2-0 (0%)
Money Meter
$-20.00
ROI
-100.0%
Betslip #1762531076799-53c6-436

Make sure to check out Sports Interaction’s complete list of NFL game oddsNFL futures and NFL specials and props.

Jonathan Taylor Over 91.5 rushing yards

I’m expecting a big performance from Jonathan Taylor in Germany this week. The Falcons have the top passing defence in the NFL, but rank just 23rd against the rush, so Indianapolis should focus on the run and give Taylor a lot of touches.

Taylor is averaging just under 100 rushing yards per game and he has topped this number five times this season.

Breece Hall Under 66.5 rushing yards

I’ll fade Breece Hall when the Jets host Cleveland. The Browns boast a top three defence in the NFL and they’re holding opposing teams to an average of just 94.3 rushing yards per game.

Hall has struggled against top tier defences this season, generating only 29 rushing yards against the Bills, 21 against the Bucs and 59 against the Broncos.

New York is also in absolute tank mode after trading away Sauce Gardner and Quinnen Williams, so they could trail early and be forced to rely on Justin Fields slinging the ball (good luck with that).

Jahmyr Gibbs first TD scorer

Usually I avoid first TD scorer props, but I feel comfortable with Lions running back Jahmyr Gibbs to score first in Washington on Sunday as Detroit has scored first in five straight games.

The Lions also struggled to generate a rushing attack last week, something I think they will focus on fixing. That means establishing the run early and letting Gibbs and David Montgomery take over the game.

Saquon Barkley anytime TD

The Monday Nighter between the Eagles and Packers is the game of the week in my mind and I’m expecting Saquon Barkley to shine.

Barkley has torched Green Bay for six TDs in four career games, including a two-TD, 109-yard performance last season.

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