Jaguars vs. 49ers Prediction, Odds & Stats - September 28, 2025

Final Score
Jacksonville
Jaguars
San Francisco
49ers
26
21
Jacksonville Jaguars
San Francisco 49ers
Scoreboard 1 2 3 4 Odds
Jacksonville Jaguars 10-4 0 17 9 0 +45.5
San Francisco 49ers 10-4 3 3 8 7 -3

Latest Encounters

Date Result Competition Stats Recap
12/14/25
Tennessee Titans TEN ( 2-12 )
San Francisco 49ers SF ( 10-4 )
24   -   37
AFC South
12/14/25
N.Y. Jets Jets NYJ ( 3-11 )
Jacksonville Jaguars JAC ( 10-4 )
20   -   48
AFC East
12/07/25
Indianapolis Colts IND ( 8-6 )
Jacksonville Jaguars JAC ( 10-4 )
19   -   36
AFC South
11/30/25
Jacksonville Jaguars JAC ( 10-4 )
Tennessee Titans TEN ( 2-12 )
25   -   3
AFC South
11/30/25
San Francisco 49ers SF ( 10-4 )
Cleveland Browns CLE ( 3-11 )
26   -   8
NFC West
11/24/25
Carolina Panthers CAR ( 7-7 )
San Francisco 49ers SF ( 10-4 )
9   -   20
NFC South
11/23/25
Jacksonville Jaguars JAC ( 10-4 )
Arizona Cardinals ARI ( 3-11 )
27   -   24
AFC South
11/16/25
San Francisco 49ers SF ( 10-4 )
Arizona Cardinals ARI ( 3-11 )
41   -   22
NFC West
11/16/25
L.A. Chargers Chargers LAC ( 10-4 )
Jacksonville Jaguars JAC ( 10-4 )
6   -   35
AFC West
11/09/25
L.A. Rams Rams LAR ( 11-3 )
San Francisco 49ers SF ( 10-4 )
42   -   26
NFC West
11/09/25
Jacksonville Jaguars JAC ( 10-4 )
Houston Texans HOU ( 9-5 )
29   -   36
AFC South
11/02/25
San Francisco 49ers SF ( 10-4 )
N.Y. Giants Giants NYG ( 2-12 )
34   -   24
NFC West

Betting Action

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
Jacksonville Jaguars Jacksonville Jaguars
2 1 7-3 5W 2-1 0 0-0 0-0 1-2
San Francisco 49ers San Francisco 49ers
3 0 7-3 4W 2-1 0 0-0 0-0 1-2

Recent Meetings

date home-away ats o/u SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards JAC:Total Net Yards JAC:Net Rushing Yards JAC:Passing Yards
09/28/2025 SF 21 - JAC 26 JAC +4.5 Over 45.5 389 83 306 325 151 174
11/12/2023 JAC 3 - SF 34 SF -3 Under 44.5 437 144 293 221 59 162
11/21/2021 JAC 10 - SF 30 SF -7 Under 45 333 171 162 200 54 146
12/24/2017 SF 44 - JAC 33 SF +5 Over 43 472 92 380 369 131 238
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/14/2025 JAC 48 - NYJ 20 W -12.5 Over 40.5 284 130 154
12/07/2025 JAC 36 - IND 19 W +1.5 Over 45.5 285 89 196
11/30/2025 TEN 3 - JAC 25 W -7 Under 41.5 272 70 202
11/23/2025 ARI 24 - JAC 27 W -2.5 Over 47.5 371 134 237
11/16/2025 JAC 35 - LAC 6 W +3 Under 43.5 135 42 93
11/09/2025 HOU 36 - JAC 29 L +3.5 Over 37.5 213 94 119
11/02/2025 LV 29 - JAC 30 L -2 Over 44 367 151 216
10/19/2025 JAC 7 - LAR 35 L +3 Under 45.5 271 89 182
10/12/2025 JAC 12 - SEA 20 L -1.5 Under 47.5 346 60 286
10/06/2025 JAC 31 - KC 28 W +3 Over 45.5 476 158 318
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
12/14/2025 SF 37 - TEN 24 W -12.5 Over 44.5 430 138 292
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 253 138 115
11/24/2025 SF 20 - CAR 9 W -7 Under 49 340 147 193
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 488 36 452
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 393 74 319
11/02/2025 NYG 24 - SF 34 W -3 Over 47.5 296 117 179
10/26/2025 HOU 26 - SF 15 L +3 Under 41.5 475 157 318
10/19/2025 SF 20 - ATL 10 W -3 Under 46.5 324 174 150
10/12/2025 TB 30 - SF 19 L +2.5 Over 47 352 104 248
10/02/2025 LAR 23 - SF 26 W +8.5 Over 47.5 456 78 378

Matchup Edge - Scoring Stats

Jacksonville Jaguars JAC
San Francisco 49ers SF
avg rank edge in rank avg
26.86 8 Points Per Game 11 24.57
20.86 9 Points Allowed Per Game 10 20.93
5.86 6 1st Quarter Scoring Per Game 10 4.79
4.36 12 1st Quarter Scoring Allowed Per Game 2 2.93
8.29 6 2nd Quarter Scoring Per Game 10 7.43
4.86 5 2nd Quarter Scoring Allowed Per Game 15 7.21
5.43 11 3rd Quarter Scording Per Game 11 5.43
2.71 3 3rd Quarter Scoring Allowed Per Game 12 4.5
6.57 14 4th Quarter Scoring Per Game 13 6.71
8.5 21 4th Quarter Scoring Allowed Per Game 11 6.29
60.0 11 Red Zone Efficiency 7 63.0
335.71 16 Total Yards Per Game 10 347.5
10.26 16 Total Yards Per Play 18 10.14
4.13 23 Rushing Yards Per Play 30 3.51
32.71 15 Passing Attempts Per Game 8 34.29
10.99 8 Passing Yards Per Completion 15 10.44
1.64 6 Passing Tds Per Game 4 1.79
19.57 19 Completions Per Game 3 23.57
59.8 27 Completion % 4 68.8
87.9 23 Qb Rating 10 96.64
2.29 11 Defense Sacks Per Game 18 1.57
0.79 7 Defense Interceptions Per Game 5 0.93
0.86 4 Opponent Fumbles Per Game 8 1.21
0.36 7 Opponent Fumbles Lost Per Game 6 0.43
8.36 23 Penalties Per Game 2 5.21
70.36 30 Penalty Yards Per Game 2 37.79
16 8 Takeaway / Giveaway Differential 11 19
6.9 6 Yards Per Punt Return 4 7.16
27.23 8 Yards Per Kickoff Return 4 27.95

Odds Analysis

Team Rankings

offence
Jacksonville Jaguars JAC
Season stats rank
Total Yards 335.7 16
Passing Yards 215 18
Rushing Yards 120.71 16
Points Scored 26.86 8
Field Goal % 0.85 19
San Francisco 49ers SF
Season stats rank
Total Yards 347.5 10
Passing Yards 246.14 4
Rushing Yards 101.36 25
Points Scored 24.57 11
Field Goal % 0.94 2
defence
Jacksonville Jaguars JAC
Season stats rank
Total Yards 335.7 16
Passing Yards 215 18
Rushing Yards 120.71 16
Points Scored 26.86 8
Field Goal % 0.85 19
San Francisco 49ers SF
Season stats rank
Total Yards 347.5 10
Passing Yards 246.14 4
Rushing Yards 101.36 25
Points Scored 24.57 11
Field Goal % 0.94 2

Injuries

Jacksonville Jaguars JAC
San Francisco 49ers SF

American Football Conference Standings

National Football Conference Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player