Sports Interaction

Jaguars vs. 49ers Prediction, Odds & Stats - September 28, 2025

Final Score
Jacksonville
Jaguars
San Francisco
49ers
26
21
Jacksonville Jaguars
San Francisco 49ers
Scoreboard 1 2 3 4 Odds
Jacksonville Jaguars 13-4 0 17 9 0 +45.5
San Francisco 49ers 12-5 3 3 8 7 -3

Latest Encounters

Date Result Competition Stats Recap
01/17/26
San Francisco 49ers SF ( 12-5 )
Seattle Seahawks SEA ( 14-3 )
6   -   41
NFC West
01/11/26
San Francisco 49ers SF ( 12-5 )
Philadelphia Eagles PHI ( 11-6 )
23   -   19
NFC West
01/11/26
Buffalo Bills BUF ( 12-5 )
Jacksonville Jaguars JAC ( 13-4 )
27   -   24
AFC East
01/04/26
Tennessee Titans TEN ( 3-14 )
Jacksonville Jaguars JAC ( 13-4 )
7   -   41
AFC South
01/03/26
Seattle Seahawks SEA ( 14-3 )
San Francisco 49ers SF ( 12-5 )
13   -   3
NFC West
12/28/25
Chicago Bears CHI ( 11-6 )
San Francisco 49ers SF ( 12-5 )
38   -   42
NFC North
12/28/25
Jacksonville Jaguars JAC ( 13-4 )
Indianapolis Colts IND ( 8-9 )
23   -   17
AFC South
12/22/25
San Francisco 49ers SF ( 12-5 )
Indianapolis Colts IND ( 8-9 )
48   -   27
NFC West
12/21/25
Jacksonville Jaguars JAC ( 13-4 )
Denver Broncos DEN ( 14-3 )
34   -   20
AFC South
12/14/25
Tennessee Titans TEN ( 3-14 )
San Francisco 49ers SF ( 12-5 )
24   -   37
AFC South
12/14/25
N.Y. Jets Jets NYJ ( 3-14 )
Jacksonville Jaguars JAC ( 13-4 )
20   -   48
AFC East
12/07/25
Indianapolis Colts IND ( 8-9 )
Jacksonville Jaguars JAC ( 13-4 )
19   -   36
AFC South

Line History

Matchup Details

team win loss last 10 w/l streak ats money home away total
Jacksonville Jaguars Jacksonville Jaguars
2 1 9-1 8W 2-1 0 0-0 0-0 1-2
San Francisco 49ers San Francisco 49ers
3 0 7-3 1L 2-1 0 0-0 0-0 1-2

Recent Meetings

date home-away ats o/u SF:Total Net Yards SF:Net Rushing Yards SF:Passing Yards JAC:Total Net Yards JAC:Net Rushing Yards JAC:Passing Yards
09/28/2025 SF 21 - JAC 26 JAC +4.5 Over 45.5 389 83 306 325 151 174
11/12/2023 JAC 3 - SF 34 SF -3 Under 44.5 437 144 293 221 59 162
11/21/2021 JAC 10 - SF 30 SF -7 Under 45 333 171 162 200 54 146
12/24/2017 SF 44 - JAC 33 SF +5 Over 43 472 92 380 369 131 238
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/11/2026 JAC 24 - BUF 27 L +1 Under 51.5 340 79 261
01/04/2026 JAC 41 - TEN 7 W -12.5 Over 46 194 77 117
12/28/2025 IND 17 - JAC 23 W -7 Under 48.5 370 121 249
12/21/2025 DEN 20 - JAC 34 W +3 Over 47 346 81 265
12/14/2025 JAC 48 - NYJ 20 W -12.5 Over 40.5 284 130 154
12/07/2025 JAC 36 - IND 19 W +1.5 Over 45.5 285 89 196
11/30/2025 TEN 3 - JAC 25 W -7 Under 41.5 272 70 202
11/23/2025 ARI 24 - JAC 27 W -2.5 Over 47.5 371 134 237
11/16/2025 JAC 35 - LAC 6 W +3 Under 43.5 135 42 93
11/09/2025 HOU 36 - JAC 29 L +3.5 Over 37.5 213 94 119
date score ats o/u Total Net Yards Net Rushing Yards Passing Yards
01/17/2026 SEA 41 - SF 6 L +7 Over 45.5 281 175 106
01/11/2026 PHI 19 - SF 23 W +5.5 Under 46.5 307 140 167
01/03/2026 SF 3 - SEA 13 L +2.5 Under 48.5 173 53 120
12/28/2025 SF 42 - CHI 38 W -3 Over 51.5 496 200 296
12/22/2025 IND 27 - SF 48 W -5.5 Over 46.5 312 58 254
12/14/2025 SF 37 - TEN 24 W -12.5 Over 44.5 430 138 292
11/30/2025 CLE 8 - SF 26 W -6.5 Under 41.5 253 138 115
11/24/2025 SF 20 - CAR 9 W -7 Under 49 340 147 193
11/16/2025 ARI 22 - SF 41 W -3.5 Over 47.5 488 36 452
11/09/2025 SF 26 - LAR 42 L +6 Over 46.5 393 74 319

Matchup Edge - Scoring Stats

Jacksonville Jaguars JAC
San Francisco 49ers SF
avg rank edge in rank avg
27.88 5 Points Per Game 9 25.71
19.76 8 Points Allowed Per Game 13 21.82
5.65 7 1st Quarter Scoring Per Game 8 5.59
4.18 10 1st Quarter Scoring Allowed Per Game 9 4.06
9.24 4 2nd Quarter Scoring Per Game 8 7.71
5 4 2nd Quarter Scoring Allowed Per Game 14 7.12
6.06 8 3rd Quarter Scording Per Game 9 5.47
3.06 4 3rd Quarter Scoring Allowed Per Game 12 4.29
6.35 15 4th Quarter Scoring Per Game 12 6.76
7.18 18 4th Quarter Scoring Allowed Per Game 14 6.35
61.8 8 Red Zone Efficiency 4 65.2
337.35 11 Total Yards Per Game 7 351.41
10.19 17 Total Yards Per Play 15 10.41
4 24 Rushing Yards Per Play 27 3.78
33.12 12 Passing Attempts Per Game 9 33.76
10.99 6 Passing Yards Per Completion 14 10.44
1.71 6 Passing Tds Per Game 4 1.94
20.24 15 Completions Per Game 4 23.41
61.1 24 Completion % 3 69.3
91.09 14 Qb Rating 6 98.76
2.41 10 Defense Sacks Per Game 19 1.59
0.71 9 Defense Interceptions Per Game 5 0.94
0.76 3 Opponent Fumbles Per Game 10 1.18
0.35 8 Opponent Fumbles Lost Per Game 8 0.35
7.53 19 Penalties Per Game 2 4.88
63.53 30 Penalty Yards Per Game 3 38.29
18 7 Takeaway / Giveaway Differential 10 22
5.93 6 Yards Per Punt Return 3 6.61
27.43 6 Yards Per Kickoff Return 7 27.16

Odds Analysis

Team Rankings

offence
Jacksonville Jaguars JAC
Season stats rank
Total Yards 337.4 11
Passing Yards 222.29 12
Rushing Yards 115.06 20
Points Scored 27.88 6
Field Goal % 0.88 11
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 10
Field Goal % 0.92 6
defence
Jacksonville Jaguars JAC
Season stats rank
Total Yards 337.4 11
Passing Yards 222.29 12
Rushing Yards 115.06 20
Points Scored 27.88 6
Field Goal % 0.88 11
San Francisco 49ers SF
Season stats rank
Total Yards 351.4 8
Passing Yards 244.53 5
Rushing Yards 106.88 24
Points Scored 25.71 10
Field Goal % 0.92 6

Injuries

Jacksonville Jaguars JAC
San Francisco 49ers SF

American Football Conference Standings

National Football Conference Standings

Line Up - Last Game

Pitchers
POS Player
Hitters
POS Player
Pitchers
POS Player
Hitters
POS Player