LSU vs. Michigan State Bracket Prediction: March Madness Sweet 16 Odds

Payton Matthews | Updated Mar 27, 2019


It’s a matchup of conference champions in this East Region Sweet 16 matchup from Washington, D.C., on Friday as third-seeded LSU and No. 2 Michigan State square off.

March 29, 2019, 7:09 PM ET
Capital One Arena
Pointspread +6 -110
Moneyline +240
Over / Under o +148.5


Betting Action


Pointspread -6 -110
Moneyline -296
Over / Under u +148.5


Betting Action


The winner of this game most likely will face top-seeded and NCAA Tournament betting favourite Duke for a spot in the Final Four. LSU was the SEC regular-season champion and Michigan State won the Big Ten title in both the regular season and conference tournament. It’s the first trip to the Sweet 16 since 2006 for LSU. It’s Michigan State’s first since 2015 when it lost in the Final Four against Duke.

LSU (3) vs. Michigan State (2) NCAA Tournament Point Spread and Betting

The Spartans played one SEC team this season, winning at Florida by four points on Dec. 8. LSU was 2-1 vs. Florida this year, losing in the SEC Tournament opener to the Gators. No team has ever won a national championship after losing its conference tournament opener.

It’s the first meeting between these programs since the 1979 NCAA Tournament. The Spartans won that matchup 87-71 and would go on to win the school’s first national championship behind a player by the name of Earvin “Magic” Johnson.

Louisiana State Tigers

It’s the second straight game against a Big Ten school for LSU as it beat sixth-seeded Maryland 69-67 in the second round of the Big Dance (MSU beat Maryland by 14 in their meeting this season). Tremont Waters hit a very tough banking layup with 1.6 seconds left for the victory. Waters, who has an NBA future, finished with 12 points. Skylar Mays led the Tigers, who led by as many as 15, with 16 points. LSU shot just 36.9 percent from the field, which certainly won’t cut it against Michigan State. The Tigers are 13-4 away from home this season and only three other teams in school history have won more games away.

The Tigers’ 28 overall victories are their most since the 1999-2000 season. LSU remains without head coach Will Wade, who has been suspended indefinitely for his alleged role in potential recruiting violations. The more the Tigers win, the better chance that interim coach Tony Benford has of keeping the job permanently if Wade doesn’t return. LSU 4-9-1 ATS in its past 14 non-conference games.

Michigan St Spartans

The Spartans didn’t play very well in their Round 1 win over Bradley but were better in the second round with a 70-50 rout of No. 10 seed and fellow Big Ten school Minnesota. All-American point guard and Big Ten Player of the Year Cassius Winston had 13 points and nine assists. Xavier Tillman was the only other Spartan in double figures with 14 points. However, nine players overall had at least nine points. MSU shot 57.1 percent overall and absolutely dominated on the boards, always a staple of Tom Izzo’s teams.

The Gophers shot only 30.5 percent and 2-for-22 from deep. It’s Izzo’s 14th trip to the Sweet 16. His team is 21-2 this season when leading at halftime. Michigan State is 12-5 ATS in its past 17 following an ATS victory.