2025 CFL Week 10 Picks and Betting Odds: Keep an eye on the injury report

We’re into Week 10 of the 2025 CFL season, so it should be no surprise to see the injury bug biting every team in the league. Our Week 10 picks will be based on who we think will suit up in Week 10 and who we think will miss the action.

Let’s dive in.

Don’t forget to check out our complete list of CFL game odds, CFL futures and CFL specials and props.

BC Lions at Hamilton Tiger-Cats

The East Division-leading Ti-Cats are riding a six-game win streak that includes a Week 8 victory against the Lions. B.C. is coming off a bye following that loss to Hamilton in which they blew a 10-point lead with under four minutes left in the game.

The Tiger-Cats have been perfect since dropping their first two games of the year and it all starts with veteran quarterback Bo Levi Mitchell, who leads the CFL by a wide margin in both passing yards and passing TDs. What’s been even more impressive is Hamilton’s ability to avoid turnovers this season, something they struggled heavily with last year.

It’s been an up-and-down year for the Lions, who can’t seem to sustain any positive momentum. While Nathan Rourke has been an effective player on offence, it’s the defence that has struggled. B.C. has mainly faced backup QBs and of the three starting pivots they have played, two have thrown for over 385 yards.

It’s pretty simple this week. It’s the league’s top passer versus a defence that has been picked apart in the air. Bonus points for Hamilton that this game is at home, this should be an easy cover.

Pick: Tiger-Cats -3.5

Edmonton Elks at Montreal Alouettes

The Alouettes and Elks will each look to rebound from Week 9 losses when they meet in Montreal on Friday. The Als were embarrassed in a 34-6 blowout against Saskatchewan, while Edmonton fell to a league-worst 1-6 with a loss against Hamilton.

Over the last few years, Montreal hasn’t been known as an offensive juggernaut, but it’s even more glaring in the absence of starting QB Davis Alexander. Backup McLeod Bethel-Thompson has thrown four interceptions in four starts and he’s a key reason why the Als have only managed to hit the 30-point mark in a game twice this season.

It’s not much better in Edmonton. Former Montreal pivot Cody Fajardo will lead the Elks’ offence on Friday, but he’s not getting much help. Edmonton’s offensive line has really struggled this year, allowing the second-most sacks in the CFL. That’s not a good sign against an Alouettes defence that ranks third in sacks.

Montreal is a good team playing in a bad funk right now, while Edmonton is just a flat out bad team. With two backup quarterbacks playing this game, the safest pick is a low scoring affair.

Pick: Under 50.5

Ottawa RedBlacks at Toronto Argonauts

It’s a rivalry game between two 2-6 teams this week as Ottawa visits Toronto. The RedBlacks snapped a four-game losing skid with blowout over Calgary last week, while the Argos tripped up in a sloppy loss to Winnipeg.

Ottawa’s defence torched Blue Bombers backup QB P.J. Walker for three interceptions last week, but this is still a team that was crushed 29-16 by Toronto in Week 4. The RedBlacks will be better off this time around as Dru Brown will play (Dustin Crum started in Week 4), so I expect things to be closer.

Toronto seems to be in a perpetual waiting game with Chad Kelly, so it will be Nick Arbuckle under centre for the foreseeable future. Arbuckle, who has thrown multiple TD passes in four straight games, has shown flashes of the brilliance that won him Grey Cup MVP last year, but his inconsistency is also a key reason why the Argos have struggled to put W’s on the board.

Brown is a big upgrade over Crum, so I expect this game to be closer than the Week 4 matchup, but Toronto is still the better team overall. I don’t think the Argos will blow the doors off Ottawa, but they should win by a touchdown.

Pick: Argonauts -2.5

Winnipeg Blue Bombers at Calgary Stampeders

Calgary and Winnipeg both have winning records this season, but this week’s matchup all depends on the injury report. Zach Collaros and Vernon Adams Jr. are both questionable to play, so there’s still a lot to be determined ahead of Saturday’s meeting.

Bombers backup QB Chris Streveler was absolutely picked apart by the Argos last week, finishing with under 200 passing yards while throwing no TDs and three interceptions. Collaros returned to practice this week, so he’ll likely play, which is clearly a massive upgrade over Streveler.

Calgary’s backup QB, P.J. Walker, was also terrible last week and also threw three interceptions, but he did manage to put up 273 passing yards and find the end zone once. The good news for the Stamps, is Adams was back at practice this week, although his reps were limited.

This game comes down to whether or not either team gets back their No. 1 quarterback. Collaros seems like he’s closer than Adams to playing, so I like getting points with the Bombers. Just remember to scour the injury reports prior to making your picks for this game.

Pick: Blue Bombers +5