Seahawks vs. 49ers Point Spread: NFL Week 2 Odds, Prediction

Edgar Chaput | Updated Sep 14, 2022

After some unexpected results in their respective Week 1 contests, this NFC West rivalry is renewed when the Seahawks drop by Levi’s Stadium to tussle with the 49ers.

September 18, 2022, 4:05 PM ET
Levi's Stadium
Pointspread +8.5 -113
Moneyline +297
Over / Under o +39.5


Betting Action


Pointspread -8.5 -106
Moneyline -363
Over / Under u +39.5


Betting Action


The game is scheduled for Sunday at 4:05 pm EST.

The 49ers hope home cooking will do them some good. They not only started the season with a defeat on the road to Chicago but had to survive what looked like an Illinois typhoon.

Currently, the 49ers are -10.5 favourites with a total points prediction of 42.5.

NFL Point Spread and Betting Analysis

These teams play each other twice per season and don’t care for each other much even though the casts have changed. Memories like Michael Crabtree swatting away Richard Sherman’s congratulatory hand are far behind us.

Despite that San Francisco’s overall recent history surpasses that of Seattle, the truth is that the Bay Area boys don’t do well against their Northwestern opponents. Last year Shanahan guided his club to the NFC Championship yet was 0-2 to the Seahawks in the regular season. In 2019 they reached the Super Bowl yet were 1-1 against Carrol’s club. They’ve lost 4 in a row to Seattle.

ATS, San Francisco emerged from the 2021 season 13-7, including the playoffs. It probably helps that they generally lose or win close games (and win more often than they lose). Conversely, the Seahawks were 9-8. Not bad for a team that missed the postseason. Seattle certainly covered Monday night, whereas San Francisco failed as -6.5 favourites in the Windy City.

Seattle Seahawks

The mighty 12th Man deserves to bask in the glory of Monday Night Football victory. The pundits said the team wasn’t good, neither quarterback has earned plaudits over their careers, and the visiting team was said to have improved its lineup considerably during the summer by signing…oh, Russell Wilson! After 3 hours of play, it was QB Geno Smith and the Seahawks who celebrated a 17-16 win.

Smith was fine. The team cooled off in the second half as Seattle scored 0 points. The ball was distributed around nicely to the entire receiving corps even though the total passing offence was nothing to write home about. Even the running game lagged behind Denver’s. What Seattle did do well was look almost like the Legion of Boom. Forcing not one but two turnovers while defending the goal line will get you places. For all sorts of small and big reasons, it was Seattle’s night.

Key Injuries: S Jamal Adams (out)

San Francisco 49ers

Kyle Shanahan will be hoping for sunnier skies in Week 2 in more ways than one. The Trey Lance era continues, as the second-year QB has another Sunday to demonstrate why the coaching staff believes he is their man. Week 1 didn’t go as planned (13/28 for 164 yards), but better quarterbacks have played worse in such dire conditions. Despite the lowly 10 points scored, at least there were hints of what the offence’s receiving corps can do, with Brandon Aiyuk, Jauan Jennings, and Deebo Samuel all getting in on the action, in addition to the latter doing his typical damage on the ground as well.

Rushing was in fact San Francisco’s strength, as they collectively slipped and slid their way to 176 yards total. 3rd down efficiency was a stellar 47%. The context of the game against the Bears feels like what caused the downfall. Now they have a chance to prove themselves.

Key Injuries: TE George Kittle (questionable), RB Elijah Mitchell (injured reserve)

NFL Prediction: Who Will Win Seahawks vs. 49ers?