Saints vs. Titans Point Spread: NFL Week 10 Odds, Prediction

Andrew Rogers | Updated Nov 11, 2021

The Tennessee Titans continue rolling along without their franchise running back – and they can move one step closer to locking up the AFC South Division title Sunday afternoon as they host the New Orleans Saints.

November 14, 2021, 1:00 PM ET
Nissan Stadium
Pointspread +3 -118
Moneyline +140
Over / Under o +42.5


Betting Action


Pointspread -3 -105
Moneyline -168
Over / Under u +42.5


Betting Action


The Titans have reeled off five consecutive victories and now own a three-game advantage over the runner-up Indianapolis Colts in the AFC South. But, New Orleans should provide a stiff challenge as they looks to bounce back from last week’s loss to lowly Atlanta.

Tennessee is a 3-point favourite to win on the NFL odds, with a total of 44.5.

NFL Point Spread and Betting Analysis

The indefinite loss of Derrick Henry has knocked Tennessee down a peg in the eyes of sports books, who only have the Titans as modest favourites despite being on home turf and owning the top record in the AFC entering the weekend. The Titans have also been one of the strongest cover options in the league to date with a 7-2 against the spread mark (including a 3-1 record at home). The Saints, meanwhile, are a sizzling 14-2 straight up in their last 16 games vs. AFC opponents.

More than three-quarters of Sports Interaction bettors have sided with the Titans so far, while 68 per cent are taking the U44.5 at -110. Both teams are operating right around the break-even point O/U for the season, with Tennessee at 5-4 and New Orleans at 4-4. But the Saints have been a far superior Over option in recent weeks (4-1 O/U in their past five games), while the Saints are on a 12-6 O/U run in their previous 18 outings.

New Orleans Saints

It was thought by many that the loss of Jameis Winston to a season-ending knee injury would open the door for a healthy Taysom Hill to shine as the starter. But it might not be that simple. Even with Hill now back from a concussion suffered in Week 5, he might face competition from Trevor Siemian, who started in last week’s loss to the Falcons and was effective, throwing for 249 yards with a pair of touchdowns and zero interceptions.

Tennessee Titans

The Titans couldn’t do much of anything on the ground in last week’s 28-16 win over the Rams (turning 26 carries into just 69 yards), and might struggle to even get to that level Sunday against a Saints defence allowing the fewest rushing yards per game in the NFL. That puts all of the pressure on quarterback Ryan Tannehill, who threw for just 143 yards with one score and one INT last week and has a 5-5 TD-to-INT ratio at home this season.

NFL Prediction: Who Will Win Saints vs. Titans?