Rams vs. 49ers Point Spread: NFL Week 10 Odds, Prediction

Payton Matthews | Updated Nov 09, 2021

Prime-time on Monday night is reserved for the NFC West with the San Francisco 49ers hosting the Los Angeles Rams.

L.A. Rams
November 15, 2021, 8:15 PM ET
Levi's Stadium
Pointspread -4 -113
Moneyline -201
Over / Under o +50


Betting Action


Pointspread +4 -107
Moneyline +164
Over / Under u +50


Betting Action


Yet another prime-time game for the Los Angeles Rams on Monday night as they visit the disappointing and NFC West rival San Francisco 49ers to close Week 10. The Rams opened as 4-point favourites to win on the NFL odds with a total of 49.5 points.

NFL Point Spread and Betting Analysis

It’s the first of two meetings between the Rams and 49ers, with Los Angeles hosting San Francisco in Week 18. That game likely will mean something to the Rams in terms of playoff positioning but not the Niners. If San Francisco loses this, the season is essentially over at 3-6. Then it might be time for Coach Kyle Shanahan to bench inconsistent veteran QB Jimmy Garoppolo for rookie No. 3 overall pick Trey Lance. We may see Lance on Monday but only for an occasional play or two barring an injury to Jimmy G.

San Francisco was 2-0 vs. Los Angeles last year, winning the game at Levi’s Stadium 24-16. That might have been Garoppolo’s best game of an injury-plagued season with three TD passes and no turnovers. George Kittle caught seven passes for 109 yards and a TD. Jared Goff was the Rams’ quarterback then but it’s of course Matthew Stafford now.

The underdog has covered four straight games in this series.

Los Angeles Rams

It seems as if the star-studded Rams are on prime-time every week. They were shocked at home last Sunday night by the Tennessee Titans as Matthew Stafford had his worst game since being traded from Detroit with back-to-back terrible interceptions in the second quarter, one returned for a touchdown. He does lead the league with 2,771 passing yards. Cooper Kupp leads with 74 catches, 1,019 yards and 10 receiving TDs. The Rams might have taken the Titans a bit lightly after they lost star running back Derrick Henry the week of the game. Future Hall of Fame pass-rusher Von Miller, acquired from Denver last week, didn’t play vs. Tennessee due to a minor injury but should debut here. The Rams are 12-3-1 ATS in their past 16 after a loss.

San Francisco 49ers

Everything was in place for the Niners to get to .500 on Sunday and win their second game in a row as Arizona was without star QB Kyler Murray and All-Pro wideout DeAndre Hopkins, yet San Francisco laid an egg in a 31-17 home loss. The Cardinals still managed 437 yards against what is supposed to be a good defence. Niners Pro Bowl tight end George Kittle returned from a long injury absence with six catches for 101 yards and a TD. Starting right tackle Mike McGlinchey suffered a torn quadriceps and will miss the season. Wide receiver Mohamed Sanu (knee sprain) and safety Tavon Wilson (foot) are expected to miss some time. Cornerbacks Josh Norman (ribs) and Dre Kirkpatrick (ankle) will be limited this week. The 49ers are 1-5 ATS in their past six games.

NFL Prediction: Who Will Win Rams vs. 49ers?