Panthers vs. Giants Point Spread: NFL Week 2 Odds, Prediction

Nik Kowalski | Updated Sep 14, 2022

Baker Mayfield and the Carolina Panthers hit the road for the first time this season with a destination of the Big Apple for a clash with the unbeaten New York Giants.

September 18, 2022, 1:00 PM ET
MetLife Stadium
Pointspread -1 -112
Moneyline -124
Over / Under o +43.5


Betting Action


Pointspread +1 -107
Moneyline +103
Over / Under u +43.5


Betting Action


Both clubs had their Week 1 contests come down to last-second field goals against them. Unfortunately for Carolina, they got a bad outcome and fell 26-24 after a 58-yard field goal from Cleveland. New York got lucky with Tennessee missing their 47-yard game-winning field goal which resulted in a 21-20 Giants win.

Even though it’s Week 2 the stakes continue to be high: top draft picks Mayfield and also Daniel Jones in New York are both in “prove-it” seasons at quarterback – each game is a must-have.

Kickoff at MetLife Stadium is set for 1 p.m. EDT with the home Giants -2.5 on the spread and the over-under at 43 on the NFL odds.

NFL Point Spread and Betting Analysis

The Panthers came out of Week 1 with an against the spread loss and their game finishing over the total, and New York did the opposite winning outright as a 5.5-point underdog while going under the total. With the loss, Carolina’s now on an eight-game losing streak both winning outright and ATS that dates back to last season.

Head-to-head, the Panthers are 1-5 ATS in their last six versus the Giants and the over is 4-1 in their last five meetings played in New York. The under’s now hit in 10 of the Giants’ last 12 outings and all of their last five home games, so another trend to think about.

Carolina Panthers

Mayfield’s Panthers debut wasn’t all too inspiring, as Carolina entered the fourth quarter with one possession ending in a score. A 75-yard touchdown strike to Robbie Anderson got Mayfield over 200 passing yards on the game as he finished with 235 yards, one touchdown, and one interception. Christian McCaffrey didn’t do a ton either with 57 yards on 14 touches.

Cleveland pounded the ball for 217 rushing yards on Carolina too. The Giants are a run-first offence, which is lining up be a potential matchup nightmare for the Panthers defence that was on the field for nearly 39 minutes in Week 1.

New York Giants

The only reason the Giants ended up with a regulation win was from a gutsy two-point play call from first-year head coach Brian Daboll. The gamble paid off as Jones hit Saquon Barkley on the two-point play giving New York a one-point lead with just over a minute to go. The biggest takeaway from Week 1 for the Giants had to be Barkley. The 2018 second-overall pick was a monster on the ground with 164 yards on 18 carries and a touchdown, while also hauling in six catches for 30 yards. On the flip side, the Giants let up 266 yards on the ground. Long story short, look at some running back overs on both sides in this tilt.

NFL Prediction: Who Will Win Panthers vs. Giants?