Panthers vs. Cardinals Point Spread: NFL Predictions, Week 3 Odds

Andrew Rogers | Updated Sep 18, 2019

kyler murray cardinals

Cardinals rookie phenom Kyler Murray looks to surpass the 300-yard plateau for the third consecutive game, something not even Carolina counterpart Cam Newton did in his first year.

September 22, 2019, 4:05 PM ET
State Farm Stadium
Pointspread +2.5 -105
Moneyline +125
Over / Under o +45


Betting Action


Pointspread -2.5 -115
Moneyline -150
Over / Under u +45


Betting Action


It’s supposed to be a matchup of two former Heisman Trophy winners and No. 1 overall picks – but an injury might end up spoiling this party as the Arizona Cardinals entertain the Carolina Panthers. Newton is questionable for this game after aggravating a foot injury.

NFL Point Spread and Betting Analysis

Carolina Panthers at Arizona Cardinals

  • Arizona Cardinals -115 -2
  • Carolina Panthers -105 +2

Newton’s injury has barely moved the line, which opened at Carolina -3.5. The Cardinals have fared well as a home underdog of late, having gone 7-4-1 ATS in their previous 12 instances with four outright victories and a Week 1 tie with the Detroit Lions. The Panthers, on the other hand, have covered just two of their previous 10 games overall and are on a five-game streak of non-covers against teams with losing records.

The total for this game has risen two points from an opening of 44.5. And both sides have seen fairly significant under trends in recent games; the Panthers have gone below the total five consecutive times against teams with losing records and are 5-2 to the under in their previous seven games overall. And the Cardinals are a sizzling 21-8 in favour of the under in their last 29 home games, while the under is 20-8 in their previous 28 September outings.

Carolina Panthers

Whether Cam makes it onto the field this weekend will likely play a major role in whether the Panthers can reverse their truly ugly cover fortunes on the road; they come in having gone just 2-8 ATS in their previous 10 away contests while scoring more than 21 points just twice over that span. Whether Newton plays or not, expect to see plenty of running back Christian McCaffrey, who has a whopping 47 touches through the first two weeks.

Arizona Cardinals

It looks like new Cardinals head coach Kliff Kingsbury will live and die by the pass. Through his first two games of NFL action, Kingsbury has called 82 pass attempts compared with just 34 runs – and you can’t even blame game script, with Arizona earning a tie in Week 1 and losing by just six in Week 2. For that reason, it’s safe to say that the over on Murray’s passing total will be an attractive weekly option until oddsmakers are able to adjust.

Who Will Win Panthers vs. Cardinals?