Colts vs. Jaguars Point Spread: NFL Week 2 Odds, Prediction

Nik Kowalski | Updated Sep 14, 2022

It’s the Indianapolis Colts and Jacksonville Jaguars squaring off in Week 2, as Indy continues their divisional road trip to kick off the year.

September 18, 2022, 1:00 PM ET
TIAA Bank Field
Pointspread -3 -113
Moneyline -171
Over / Under o +43.5


Betting Action


Pointspread +3 -107
Moneyline +142
Over / Under u +43.5


Betting Action


The AFC South is still seeking its first win of the 2022–23 NFL season, but as we saw last week even when two clubs go head-to-head… a win isn’t guaranteed. That’s because the Colts tied divisional foe Houston last weekend, and Jacksonville lost at Washington. The division’s fourth team, Tennessee, lost hosting the Giants.

Now Indianapolis and Jacksonville meet for the first time this season, just over eight months after the last-place Jaguars spoiled the Colts’ playoff hopes in an upset victory. So revenge will certainly be on the minds of the Colts.

Kickoff at TIAA Bank Field goes at 1 p.m. EDT, with the Colts 4-point favourites on the road and the over-under at 47 on the NFL odds.

NFL Point Spread and Betting Analysis

For Jacksonville, their recent betting trends are ugly… unless it’s against Indianapolis. Jacksonville is 2-13 outright in their last 15 home games and 1-8 against the spread in their last nine overall. But at home against the Colts, Jacksonville has covered six straight times.

Both teams failed to cover last week, with the Colts going under the total and the Jaguars over. Dating back to last season Indianapolis’ last six games have now all gone under. Indianapolis has struggled to cover too, win just one ATS win in their last 10 outings overall.

Indianapolis Colts

A 17-point point rally in the fourth quarter saved the Colts from an embarrassing season-opening loss in a game where they were favoured on the road by a touchdown. Matt Ryan ended up leading two touchdown drives in the fourth, and then what looked like a game-winning overtime drive but the since-released Rodrigo Blankenship missed his 42-yard winning field goal. Either Chase McLaughlin or Lucas Havrisik will kick for Indianapolis this week.

Last season’s rushing champ, Jonathan Taylor, got 35 touches in the tie, finishing with 161 rushing yards and another 14 receiving along with a touchdown. Michael Pittman Jr.’s looking like a true top receiver in his third year after a game-high nine grabs for 121 yards and a touchdown in week 1.

Jacksonville Jaguars

Jacksonville held an eight-point lead in the final frame at Washington but surrendered back-to-back touchdowns in what became a disappointing 28-22 defeat. Both teams registered over 380 yards of offence.

Christian Kirk was Jacksonville’s big money free agent addition and played like it in his debut with six grabs for a game-high 117 receiving yards. James Robinson saw the most touches in the Jags backfield with 11 carries for 66 yards along with a rushing and receiving touchdown.

The 2022 first-overall draft pick, Travon Walker, made his presence felt in his NFL debut with four tackles, a sack, one interception, and a tackle for a loss. Jacksonville’s defence allowed 313 yards through the air against Washington, and the air yards may pour on again versus the Colts.

NFL Prediction: Who Will Win Colts vs. Jaguars?