Chargers vs. Chiefs Point Spread: NFL Week 3 Odds, Prediction

Andrew Rogers | Updated Sep 23, 2021

It might be just the third week of the NFL season, but neither the Los Angeles Chargers nor the Kansas City Chiefs can afford another loss as they tangle Sunday at Arrowhead Stadium.

September 26, 2021, 1:00 PM ET
Arrowhead Stadium
Pointspread +7 -110
Moneyline +250
Over / Under o +56


Betting Action


Pointspread -7 -110
Moneyline -303
Over / Under u +56


Betting Action


This is the first of two meetings between the top two betting faves to win the AFC West title, the Chiefs and Chargers. Both teams have opened the season 1-1, while the division-rival Las Vegas Raiders and Denver Broncos are both 2-0.

Kansas City is a 7-point favourites to win on the NFL odds, with a total of 55.0.

NFL Point Spread and Betting Analysis

Oddsmakers have the Chiefs on the magic number; you can avoid the push by taking the Chiefs -6.5 at -114, or the Chargers +7.5 at -135 depending on who you like. Nearly two-thirds of the Sports Interaction betting public are on Kansas City, who have gone a dreadful 1-10-1 against the spread in their previous 12 games as a favourite. The Chargers, meanwhile, are an impressive 8-7 straight up and 10-5 ATS in their previous 15 as a road underdog.

You’re probably going to see plenty of scoring in Sunday’s key divisional matchup, with the total set at a sky-high 55. And that’s still not high enough to deter totals bettors, with nearly 80 per cent taking the Over. That’s quite close to the 53-point average these teams have posted in six head-to-head meetings in the Patrick Mahomes Era, with the clubs combining to go 4-2 O/U in that span. And the Chargers are 10-3 O/U in their last 13 road games.

Los Angeles Chargers

Both of these teams rely heavily on their standout young quarterbacks – and while the points haven’t quite been there yet for the Chargers (18.5 ppg), Justin Herbert has been as good as advertised through two games. The second-year QB is completing more than 70 per cent of his pass attempts while racking up 675 yards to date. The problem? Interceptions: he has already been picked off three times, after tossing just 10 INTs in 15 games as a rookie.

Kansas City Chiefs

Travis Kelce is at it again. The future Hall of Fame tight end is off to a blistering start so far in 2021, hauling in 13 passes (on just 15 targets) for 185 yards and three touchdowns. He ranks second in the NFL in receiving yards since the start of the 2018 season, behind only DeAndre Hopkins – and while he has never led the league in a single season, his current odds of +1305 to do so in 2021 might just be one of the sneakiest underdog NFL player props out there.

NFL Prediction: Who Will Win Chargers vs. Chiefs?