Cardinals vs. Browns Point Spread: NFL Week 6 Odds, Prediction

Andrew Rogers | Updated Oct 13, 2021

Nick Chubb and Kareem Hunt, Browns, 2021

Nick Chubb and Kareem Hunt are arguably the best dynamic duo in the league, feeding off of one another to ease the pressure off of Baker Mayfield.

October 17, 2021, 4:05 PM ET
FirstEnergy Stadium
Pointspread +3 -128
Moneyline +120
Over / Under o +48.5


Betting Action


Pointspread -3 +107
Moneyline -144
Over / Under u +48.5


Betting Action


The only undefeated team left in the NFL is the Arizona Cardinals and they’ll have to face a stiff test on Sunday in order to maintain their flawless record. The Arizona Cardinals are going to take a trip to face the Cleveland Browns in what should be the best game of the week. Arizona held off the San Francisco 49ers in their last game while the Browns somehow lost a game in which they totaled over 500 yards of offense without a single turnover. Will Arizona remain unbeaten or will Cleveland be the first to tarnish their record?

NFL Point Spread and Betting Analysis

The Cardinals have covered three straight overall as well as three straight on the road. The under has been strong for the Cardinals lately as it has hit in five of their last six games on the road when they’re posted as the underdog.

As for Cleveland, they have struggled mightily during the month of October. They are just 5-20 straight up in their last 25 games in the month. However, the Browns are 8-1 straight up in their last nine games when coming into the matchup as the favorite.

Arizona Cardinals

Kyler Murray and the Cardinals aren’t a team to sleep on anymore. In four of their five games, they have completely dominated their opposition – including both the Los Angeles Rams and the Tennessee Titans, two teams who made the playoffs last season. Murray hasn’t thrown an interception in two games and has a multitude of weapons at his disposal to keep him from doing so. However, their defense hasn’t been talked about enough in the midst of this great season they are having. Arizona is currently allowing the fourth-best conversion rate when it comes to third downs this year. There aren’t many teams out there right now doing what the Cardinals are doing on both sides of the ball.

Cleveland Browns

If the Browns are going to win on Sunday, it’s going to be because of their ground game. Nick Chubb and Kareem Hunt are arguably the best dynamic duo in the league, feeding off of one another to ease the pressure off of Baker Mayfield. Despite Odell Beckham’s return to the lineup two weeks ago, he hasn’t really been involved in the offense and their passing game has struggled because of it. Once one of the most feared receivers in the league, Beckham has just nine catches for 124 yards on the season with no touchdowns. It’s clear that this team wins on the ground and any success through the air comes secondary to that.

On defense, Cleveland’s pass rush also flatlined in their last game without Jadeveon Clowney to line up across from Myles Garrett. They need him back as slowing down Kyler Murray, who already has 13 total touchdowns on the year and is third in QBR, will not be easy.

Who Will Win Cardinals vs. Browns?