The San Francisco 49ers and New York Giants both look vastly different from how they did just one week ago as they duel Sunday in East Rutherford, N.J.
Pointspread | -3 -112 |
Moneyline | -172 |
Over / Under | o +43.5 |
Pointspread | +3 -108 |
Moneyline | +140 |
Over / Under | u +43.5 |
The 49ers are the only team in the NL West with a loss and has lost several starters to injury, while the Giants will need to find a way to make up for the loss of Saquon Barkley. The sensational running back suffered a torn ACL in last week’s defeat and will miss the remainder of the season.
NFL Point Spread and Betting Analysis
The 49ers are caught between magic numbers at -4.5, the byproduct of several expected Week 3 absences – including starting quarterback Jimmy Garoppolo, running back Raheem Mostert and standout defensive lineman Nick Bosa. The 49ers have gone a healthy 4-1 ATS in their last five games as a favourite while the Giants are a dreadful 1-7 against the spread in their last eight September home games. 75 percent of Sports Interaction bettors are on the 49ers.
The total for Sunday’s encounter is set at a super-low 41.5, with Sports Interaction respondents split right down the middle. New York has gone below the number in their previous six home games in September, with three of those outings coming in under 40 total points. And San Francisco also has a solid Under trend working in its favour, with five of its previous seven games on the East Coast coming in below the number.
San Francisco 49ers
Being down a starting QB, a No. 1 RB and possibly a star TE (George Kittle is questionable) is not ideal, but losing Bosa might hurt this team the most. The team’s defensive lynchpin was carted off the field in last weekend’s 31-13 win over the Jets, and the team confirmed his torn ACL the following day. The 49ers defence will need to step up in his absence, particularly if Garoppolo sits out and Nick Mullens takes over under center.
New York Giants
The Giants are also hurting on offence, most significantly due to the loss of Barkley. His season-ending injury resulted in New York signing free-agent running back Devonta Freeman to a one-year contract earlier in the week; it’s unclear how Freeman will factor into the offence this weekend, but he’ll likely share work with Wayne Gallman and Dion Lewis. Wide receiver Sterling Shepard is also out, having been placed on the IR earlier this week with turf toe.
NFL Prediction: Who Will Win 49ers vs. Giants?
Line History
Sports Interaction customers are placing their bets on:
time | fav | line | total |
---|---|---|---|
Opening 18 Sep 1:58pm | SF | -6.5 -110 | O +42.5 -110 |
Closing 27 Sep 4:23pm | SF | -3 -112 | U +43.5 -110 |
- Regular Season
49ers Team Leaders
Touchdowns |
10 |
Rushing |
600 |
Passing |
2437 |
Receiving |
60 |
Sacks |
8.5 |
Interceptions |
2 |
Touchdowns |
6 |
Rushing |
682 |
Passing |
2943 |
Receiving |
66 |
Sacks |
11.5 |
Interceptions |
3 |
- Regular Season
Giants Team Leaders
Touchdowns |
10 |
Rushing |
600 |
Passing |
2437 |
Receiving |
60 |
Sacks |
8.5 |
Interceptions |
2 |
Touchdowns |
6 |
Rushing |
682 |
Passing |
2943 |
Receiving |
66 |
Sacks |
11.5 |
Interceptions |
3 |
Weather

temp | 75 |
condition | cloudy |
wind | South 2mph |
Injuries
Kevin Givens (DL)
Dre Greenlaw (LB)
Emmanuel Moseley (CB)
Justin Skule (T)
Jordan Willis (DL)
Robbie Gould (K)
Mark Nzeocha (LB)
K'Waun Williams (CB)
Tarvarius Moore (DB)
Brandon Aiyuk (WR)
Cam Brown (LB)
Jabrill Peppers (S)
Sterling Shepard (WR)
Elijhaa Penny (RB)
Blake Martinez (LB)
Golden Tate (WR)
Evan Engram (TE)
Kaden Smith (TE)
James Bradberry (CB)
Daniel Jones (QB)
Injuries
player (position) | status | ats*current | o/u* | notes | |
---|---|---|---|---|---|
Kevin Givens (DL) | Out Sun | Undisclosed - 01 / 01 / 21 | 1-0 | 0-1 | + - |
Givens will be unavailable for Sunday's clash against the Seahawks for unlisted reasons. |
|||||
Dre Greenlaw (LB) | Out Sun | Calf - 01 / 01 / 21 | 1-0 | 0-1 | + - |
Greenlaw has a calf injury, and it will keep him on the sidelines versus the Seahawks on Sunday. |
|||||
Emmanuel Moseley (CB) | Ques Sun | Hamstring - 31 / 12 / 20 | 1-0 | 0-1 | + - |
Moseley is battling a hamstring issue, and it is unknown if he will be good to go against the Seahawks on Sunday. |
|||||
Justin Skule (T) | Ques Sun | Knee - 31 / 12 / 20 | 1-0 | 0-1 | + - |
Skule has a knee injury, and it remains to be seen if he will partake in Sunday's game against the Seahawks. |
|||||
Jordan Willis (DL) | out for season | Ankle - 31 / 12 / 20 | 1-0 | 0-1 | + - |
Willis has been placed on the injured reserve list as he has an ankle injury, ending his season. |
|||||
Robbie Gould (K) | Out indefinitely | Illness - 30 / 12 / 20 | 1-0 | 0-1 | + - |
Gould has landed on the Injured Reserve/COVID-19 list, and will be out for an unknown length of time. |
|||||
Mark Nzeocha (LB) | Ques Sun | Illness - 30 / 12 / 20 | 1-0 | 0-1 | + - |
Nzeocha is ailing from an illness, and it is unknown if he will participate against the Seahawks on Sunday. |
|||||
K'Waun Williams (CB) | Out Sun | Shin - 30 / 12 / 20 | 1-0 | 0-1 | + - |
Williams is managing a shin injury, and it will prevent him from playing against the Seahawks on Sunday. |
|||||
Tarvarius Moore (DB) | Ques Sun | Ankle - 28 / 12 / 20 | 1-0 | 0-1 | + - |
Moore is dealing with an ankle injury, leaving his status against the Seahawks on Sunday hazy. |
|||||
Brandon Aiyuk (WR) | Out Sun | Ankle - 28 / 12 / 20 | 1-0 | 0-1 | + - |
Aiyuk is battling an ankle injury, and he will not be available Sunday versus the Seahawks. |
player (position) | status | ats*current | o/u* | notes | |
---|---|---|---|---|---|
Cam Brown (LB) | Ques Sun | Illness - 01 / 01 / 21 | 0-1 | 0-1 | + - |
Brown is dealing with an illness, and it is unclear if he will line up against the Cowboys on Sunday. |
|||||
Jabrill Peppers (S) | day-to-day | Ankle - 30 / 12 / 20 | 0-1 | 0-1 | + - |
Peppers left the last game with an unknown injury, and his status is unknown moving forward. |
|||||
Sterling Shepard (WR) | Ques Sun | Ribs - 30 / 12 / 20 | 0-1 | 0-1 | + - |
Shepard is bothered by a rib injury, leaving his status against the Cowboys on Sunday clouded. |
|||||
Elijhaa Penny (RB) | I-R | Illness - 27 / 12 / 20 | 0-2 | 0-2 | + - |
Penny is on the injured reserve list due to an illness, and it is unknown how long he will be out. |
|||||
Blake Martinez (LB) | Prob Sun | Ankle - 26 / 12 / 20 | 0-2 | 0-2 | + - |
Martinez has an ankle injury, but it is not expected to keep him off the lineup card Sunday against the Ravens. |
|||||
Golden Tate (WR) | day-to-day | Calf - 24 / 12 / 20 | 0-2 | 0-2 | + - |
Tate was held out of the last two contests with a calf injury, and it is unknown if he will line up for postseason games. |
|||||
Evan Engram (TE) | Prob Sun | Calf - 19 / 12 / 20 | 0-3 | 0-3 | + - |
Engram is tending to a calf injury, but he is expected to lace up against the Browns on Sunday. |
|||||
Kaden Smith (TE) | Ques Sun | Knee - 17 / 12 / 20 | 0-3 | 0-3 | + - |
Smith is dealing with an injury to his knee, and is up in the air if it will impact his status for Sunday's matchup with the Browns. |
|||||
James Bradberry (CB) | Out indefinitely | Illness - 17 / 12 / 20 | 0-3 | 0-3 | + - |
Bradberry has been shifted to the Injured Reserve/COVID-19 list after coming into contact with the virus, and will miss an unknown length of time. |
|||||
Daniel Jones (QB) | Prob Sun | Ankle - 16 / 12 / 20 | 0-3 | 0-3 | + - |
Jones sat out the previous game with a sprained ankle, but he projects to be in the lineup versus the Ravens on Sunday. |
-
SAN FRANCISCO 49ERS
17 -
NEW YORK GIANTS
13
Score
Prediction
-
Line History
Sports Interaction customers are placing their bets on:
time fav line total Opening 18 Sep 1:58pm SF -6.5 -110 O +42.5 -110 Closing 27 Sep 4:23pm SF -3 -112 U +43.5 -110 -
- Regular Season
49ers Team Leaders
Touchdowns 10
Rushing 600
Passing 2437
Receiving 60
Sacks 8.5
Interceptions 2
Touchdowns 6
Rushing 682
Passing 2943
Receiving 66
Sacks 11.5
Interceptions 3
-
- Regular Season
Giants Team Leaders
Touchdowns 10
Rushing 600
Passing 2437
Receiving 60
Sacks 8.5
Interceptions 2
Touchdowns 6
Rushing 682
Passing 2943
Receiving 66
Sacks 11.5
Interceptions 3
-
Weather
temp 75 condition cloudy wind South 2mph -
Injuries
Kevin Givens (DL)
Out Sun Undisclosed - 01 / 01 / 21Dre Greenlaw (LB)
Out Sun Calf - 01 / 01 / 21Emmanuel Moseley (CB)
Ques Sun Hamstring - 31 / 12 / 20Justin Skule (T)
Ques Sun Knee - 31 / 12 / 20Jordan Willis (DL)
out for season Ankle - 31 / 12 / 20Robbie Gould (K)
Out indefinitely Illness - 30 / 12 / 20Mark Nzeocha (LB)
Ques Sun Illness - 30 / 12 / 20K'Waun Williams (CB)
Out Sun Shin - 30 / 12 / 20Tarvarius Moore (DB)
Ques Sun Ankle - 28 / 12 / 20Brandon Aiyuk (WR)
Out Sun Ankle - 28 / 12 / 20Cam Brown (LB)
Ques Sun Illness - 01 / 01 / 21Jabrill Peppers (S)
day-to-day Ankle - 30 / 12 / 20Sterling Shepard (WR)
Ques Sun Ribs - 30 / 12 / 20Elijhaa Penny (RB)
I-R Illness - 27 / 12 / 20Blake Martinez (LB)
Prob Sun Ankle - 26 / 12 / 20Golden Tate (WR)
day-to-day Calf - 24 / 12 / 20Evan Engram (TE)
Prob Sun Calf - 19 / 12 / 20Kaden Smith (TE)
Ques Sun Knee - 17 / 12 / 20James Bradberry (CB)
Out indefinitely Illness - 17 / 12 / 20Daniel Jones (QB)
Prob Sun Ankle - 16 / 12 / 20Injuries
player (position) status ats*current o/u* notes Kevin Givens (DL) Out Sun Undisclosed - 01 / 01 / 21 1-0 0-1 + - Givens will be unavailable for Sunday's clash against the Seahawks for unlisted reasons.
Dre Greenlaw (LB) Out Sun Calf - 01 / 01 / 21 1-0 0-1 + - Greenlaw has a calf injury, and it will keep him on the sidelines versus the Seahawks on Sunday.
Emmanuel Moseley (CB) Ques Sun Hamstring - 31 / 12 / 20 1-0 0-1 + - Moseley is battling a hamstring issue, and it is unknown if he will be good to go against the Seahawks on Sunday.
Justin Skule (T) Ques Sun Knee - 31 / 12 / 20 1-0 0-1 + - Skule has a knee injury, and it remains to be seen if he will partake in Sunday's game against the Seahawks.
Jordan Willis (DL) out for season Ankle - 31 / 12 / 20 1-0 0-1 + - Willis has been placed on the injured reserve list as he has an ankle injury, ending his season.
Robbie Gould (K) Out indefinitely Illness - 30 / 12 / 20 1-0 0-1 + - Gould has landed on the Injured Reserve/COVID-19 list, and will be out for an unknown length of time.
Mark Nzeocha (LB) Ques Sun Illness - 30 / 12 / 20 1-0 0-1 + - Nzeocha is ailing from an illness, and it is unknown if he will participate against the Seahawks on Sunday.
K'Waun Williams (CB) Out Sun Shin - 30 / 12 / 20 1-0 0-1 + - Williams is managing a shin injury, and it will prevent him from playing against the Seahawks on Sunday.
Tarvarius Moore (DB) Ques Sun Ankle - 28 / 12 / 20 1-0 0-1 + - Moore is dealing with an ankle injury, leaving his status against the Seahawks on Sunday hazy.
Brandon Aiyuk (WR) Out Sun Ankle - 28 / 12 / 20 1-0 0-1 + - Aiyuk is battling an ankle injury, and he will not be available Sunday versus the Seahawks.
player (position) status ats*current o/u* notes Cam Brown (LB) Ques Sun Illness - 01 / 01 / 21 0-1 0-1 + - Brown is dealing with an illness, and it is unclear if he will line up against the Cowboys on Sunday.
Jabrill Peppers (S) day-to-day Ankle - 30 / 12 / 20 0-1 0-1 + - Peppers left the last game with an unknown injury, and his status is unknown moving forward.
Sterling Shepard (WR) Ques Sun Ribs - 30 / 12 / 20 0-1 0-1 + - Shepard is bothered by a rib injury, leaving his status against the Cowboys on Sunday clouded.
Elijhaa Penny (RB) I-R Illness - 27 / 12 / 20 0-2 0-2 + - Penny is on the injured reserve list due to an illness, and it is unknown how long he will be out.
Blake Martinez (LB) Prob Sun Ankle - 26 / 12 / 20 0-2 0-2 + - Martinez has an ankle injury, but it is not expected to keep him off the lineup card Sunday against the Ravens.
Golden Tate (WR) day-to-day Calf - 24 / 12 / 20 0-2 0-2 + - Tate was held out of the last two contests with a calf injury, and it is unknown if he will line up for postseason games.
Evan Engram (TE) Prob Sun Calf - 19 / 12 / 20 0-3 0-3 + - Engram is tending to a calf injury, but he is expected to lace up against the Browns on Sunday.
Kaden Smith (TE) Ques Sun Knee - 17 / 12 / 20 0-3 0-3 + - Smith is dealing with an injury to his knee, and is up in the air if it will impact his status for Sunday's matchup with the Browns.
James Bradberry (CB) Out indefinitely Illness - 17 / 12 / 20 0-3 0-3 + - Bradberry has been shifted to the Injured Reserve/COVID-19 list after coming into contact with the virus, and will miss an unknown length of time.
Daniel Jones (QB) Prob Sun Ankle - 16 / 12 / 20 0-3 0-3 + - Jones sat out the previous game with a sprained ankle, but he projects to be in the lineup versus the Ravens on Sunday.